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Given that the proposed HbA1c diagnostic for screening are both insensitive and racially discrepant, what is the optimal way to screen for diabetes? Dr. Rhee recommended that doctors perform the standard 75 gram OGTT, or, at the very least, a fasting glucose level followed by the OGTT in individuals whose levels are abnormal (100 mg/dL and above).
Findings from a recent study, she said, suggest that the 50 gram glucose challenge test, a test used to screen for gestational diabetes in pregnancy, may represent a promising alternative to HbA1c as a screening test for diabetes or prediabetes (Phillips et al. Diabetologia. 2009;52:1798-1807) because it has been shown to be accurate and can be readily performed during office visits at any time of the day and without a prior fast.

 

Prednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. It is used to treat certain inflammatory diseases and (at higher doses) cancer, but has significant adverse effects. Because it suppresses the immune system, it leaves patients more susceptible to infections.
It is also used for treating hair loss and acne in women, and can be used as a topical medication for treatment of male baldness. It is commonly used to treat symptoms of polycystic ovary syndrome (PCOS) such as excess facial hair and acne. It can also cause gynecomastia in males and should never be given with potassium supplementation for fear of the development of hyperkalemia.

 

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